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Gonjari, I. D.
- Validated Stability Indicating RP-HPLC Method for Simultaneous Determination of Metoprolol Succinate and Olmesartan Medoxomil in Tablet Dosage Form
Abstract Views :203 |
PDF Views:87
Authors
Affiliations
1 Padm. Dr. D. Y. Patil College of Pharmacy, Sector No. 29, Pradhikaran, Near ZSI Building, Akurdi, Pune - 411 044, Maharashtra, IN
2 Government College of Pharmacy, Vidyanagar, Karad - 415 124, Maharashtra, IN
3 Jawaharlal Nehru Technological University, Anantapur - 515 002, Andhra Pradesh, IN
1 Padm. Dr. D. Y. Patil College of Pharmacy, Sector No. 29, Pradhikaran, Near ZSI Building, Akurdi, Pune - 411 044, Maharashtra, IN
2 Government College of Pharmacy, Vidyanagar, Karad - 415 124, Maharashtra, IN
3 Jawaharlal Nehru Technological University, Anantapur - 515 002, Andhra Pradesh, IN
Source
Journal of Pharmaceutical Research, Vol 12, No 4 (2013), Pagination: 122-127Abstract
The present paper describes simple, rapid, reproducible, accurate and precise stability indicating HPLC method developed for quantitative simultaneous estimation of metoprolol succinate and olmesartan medoxomil in bulk and combined pharmaceutical dosage form. A chromatographic separation of both drugs was achieved with Chromasil 250 × 4.6 mm, i.d 5 μm C-18 column using methanol:0.05% v/v Ophosphoric acid in water (50:50 v/v) at the flow rate of 1ml/min. The measurements were made at 228.0 nm as detector wavelength. The described method showed excellent linearity over a range of 5-80 μg/ml for metoprolol succinate and 5-70 μg/ml for olmesartan medoxomil. The coefficient of correlation for metoprolol succinate and olmesartan medoxomil was found to be 0.9990 and 0.9993 respectively. The retention time for metoprolol succinate and olmesartan medoxomil was found to be 3.485 min and 7.085 min, respectively. The tailing factor for metoprolol succinate and olmesartan medoxomil was found to be 1.02 and 1.13 respectively. Both drugs and their combination drug product were found to be stable in neutral, thermal, oxidative and photolytic stress conditions but mild degradation was observed in acidic and alkaline conditions.Keywords
Metoprolol Succinate, Olmesartan Medoxomil, HPLC Method Validation, Stability-Indicating Method, ICH Guidelines.Full Text
- Development and Validation of UV Spectrophotometric Method of Ambroxol Hydrochloride in Bulk and Pharmaceutical Formulation
Abstract Views :152 |
PDF Views:0
Authors
Chhotaram Seervi
1,
Kundan Pawar
1,
P. N. Dhabale
1,
I. D. Gonjari
1,
Chandrakant Raut
1,
Deepali Gharge
1
Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 547-549Abstract
Two simple, precise and economical UV methods have been developed for the estimation of Ambroxol Hydrochloride in bulk and pharmaceutical formulations. Ambroxol Hydrochloride has the absorbance maxima at 246.5 nm (Method A), and in the first order derivative spectra showed sharp peak at 240 nm (Method B). Linearity for detector response was observed in the concentration range of 10-50 μg/ml for all two methods. The proposed methods were successfully applied for the estimation of Ambroxol Hydrochloride in commercial pharmaceutical preparation by using simple solvent Distilled water. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, Limit of Detection and Limit of Quantification and specificity were found to be satisfactory.Keywords
Ambroxol Hydrochloride, UV Spectrophotometry, Absorbance Maxima, Derivative Spectroscopy.
- Fast Dissolving Drug Delivery System of Cilnidipine using Gelucire 50/13
Abstract Views :168 |
PDF Views:0
Authors
Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, IN
2 Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra 431005, IN
3 Government College of Pharmacy, Ratnagiri, Maharashtra 415612, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, IN
2 Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra 431005, IN
3 Government College of Pharmacy, Ratnagiri, Maharashtra 415612, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2185-2188Abstract
Cilnidipine is poorly water soluble antihypertensive drug (BCS class II). This study was conducted to increase solubility of drug. An attempt was made to formulate fast dissolving tablet of Cilnidipine by solid dispersion using melting method with Gelucire 50/13. The API: carrier was taken as 1:1, 1:2 and 1:3. Effect of several variables such as concentration of superdisintegrant, drug: carrier ratios were studied. Formulations were analyzed using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) analysis, Fourier Transform-Infrared spectroscopy (FT-IR) and in-vitro release studies followed by various release kinetics. The % drug release NLT 85% was obtained by melting method of Cilnidipine: Gelucire 50/13 (1:3) within 15 minutes. Accelerated stability study was carried out for period of 3 months, which indicated prepared formulations were stable.Keywords
Fast Dissolving Tablet, Cilnidipine, Gelucire 50/13, Melting Method, Solid Dispersion.References
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